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Tramadol e ondansetrona interagem no mesmo receptor - 5HT . Tramal sendo AGONISTA parcial dos receptores 5HT, e a Ondansetrona ANTAGONISTA dos mesmos receptores. Pela lógica você já consegue perceber que são duas medicações com mecanismos de ação contraditórios e que, por isso, se administradas de forma simultânea, terão seus efeitos reduzidos. Mas apesar disso tudo, a utilização da Ondansetrona como antiemético AINDA é a melhor escolha para as náuseas e vômitos provocadas pelo Tramal
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